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Tnfrsf13btm1Vmd
Targeted Allele Detail
Nomenclature
Symbol: Tnfrsf13btm1Vmd
Name: tumor necrosis factor receptor superfamily, member 13b; targeted mutation 1, Vishva M Dixit
MGI ID: MGI:2182823
Synonyms: TACI-
Gene: Tnfrsf13b  Location: Chr11:61126755-61149372 bp, + strand  Genetic Position: Chr11, 37.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70172
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe region of the gene encoding the transmembrane domain and intracellular domain was replaced with a PGK-neo cassette via homologous recombination. The absence of gene expression in homozygous mutant animals was verified by Northern blot analysis of total spleen RNA. (J:70172)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf13b Mutation:  9 strains or lines available
References
Original:  J:70172 Yan M, et al., Activation and accumulation of B cells in TACI-deficient mice. Nat Immunol. 2001 Jul;2(7):638-43
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory