Camp^tm1Rlg
Targeted Allele Detail

Summary

• Symbol: Camp^tm1Rlg
• Name: cathelicidin antimicrobial peptide; targeted mutation 1, Richard L Gallo
• MGI ID: MGI:2182791
• Synonyms: Camp^-, Cnlp-, Cnlp-null, Cramp-ko
• Gene: Camp Location: Chr9:109676445-109678524 bp, - strand Genetic Position: Chr9, 59.8 cM
• Alliance: Camp^tm1Rlg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72924
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4, which encode the entire mature domain of the protein, were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis using a probe to exon 4 confirmed the absence of gene expression in bone marrow of homozygous mutant animals. (J:72924)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Camp Mutation: 12 strains or lines available

References

• Original: J:72924 Nizet V, et al., Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 2001 Nov 22;414(6862):454-7
• All: 51 reference(s)