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Camptm1Rlg
Targeted Allele Detail
Nomenclature
Symbol: Camptm1Rlg
Name: cathelicidin antimicrobial peptide; targeted mutation 1, Richard L Gallo
MGI ID: MGI:2182791
Synonyms: Camp-, Cnlp-, Cnlp-null, Cramp-ko
Gene: Camp  Location: Chr9:109847379-109849617 bp, - strand  Genetic Position: Chr9, 59.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72924
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4, which encode the entire mature domain of the protein, were replaced with a PGK-neo cassette via homologous recombination. Northern blot analysis using a probe to exon 4 confirmed the absence of gene expression in bone marrow of homozygous mutant animals. (J:72924)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Camp Mutation:  4 strains or lines available
References
Original:  J:72924 Nizet V, et al., Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature. 2001 Nov 22;414(6862):454-7
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory