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Targeted Allele Detail
Symbol: Ets1tm1Jml
Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Jeffrey M Leiden
MGI ID: MGI:2182789
Synonyms: Ets-1-, Ets-1p
Gene: Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:77869
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Encoded protein was undetected via immunoblot analysis of protein extracts from homozygous mutant thymocytes. Subsequent western blot analysis has determined that 1% to 5% of endogenous levels of a protein lacking the Point domain is expressed. (J:77869, J:125056)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:  15 strains or lines available
Original:  J:77869 Muthusamy N, et al., Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 1995 Oct 19;377(6550):639-42
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
The Jackson Laboratory