About   Help   FAQ
Ets1tm1Jml
Targeted Allele Detail
Nomenclature
Symbol: Ets1tm1Jml
Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Jeffrey M Leiden
MGI ID: MGI:2182789
Synonyms: Ets-1-, Ets-1p
Gene: Ets1  Location: Chr9:32636221-32757820 bp, + strand  Genetic Position: Chr9, 17.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77869
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA region encompassing all of exon 3 and a portion of exon 4 was deleted by the insertion of a neomycin selection cassette. Encoded protein was undetected via immunoblot analysis of protein extracts from homozygous mutant thymocytes. Subsequent western blot analysis has determined that 1% to 5% of endogenous levels of a protein lacking the Point domain is expressed. (J:77869, J:125056)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:  5 strains or lines available
References
Original:  J:77869 Muthusamy N, et al., Defective activation and survival of T cells lacking the Ets-1 transcription factor. Nature. 1995 Oct 19;377(6550):639-42
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/18/2020
MGI 6.14
The Jackson Laboratory