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Hist1h1ctm1Ais
Targeted Allele Detail
Nomenclature
Symbol: Hist1h1ctm1Ais
Name: histone cluster 1, H1c; targeted mutation 1, Art I Skoultchi
MGI ID: MGI:2182775
Synonyms: H1c-
Gene: Hist1h1c  Location: Chr13:23738808-23740367 bp, + strand  Genetic Position: Chr13, 9.9 cM, cytoband A2-A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72858
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details80% of the coding region of the gene, which includes the ATG start site, was replaced with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by reverse-phase HPLC analysis of liver histone extracts. (J:72858)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hist1h1c Mutation:  12 strains or lines available
References
Original:  J:72858 Fan Y, et al., Individual somatic h1 subtypes are dispensable for mouse development even in mice lacking the h1(0) replacement subtype. Mol Cell Biol. 2001 Dec;21(23):7933-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory