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Targeted Allele Detail
Symbol: Enpeptm1Mdc
Name: glutamyl aminopeptidase; targeted mutation 1, Max D Cooper
MGI ID: MGI:2182774
Synonyms: APA-, BP-1-
Gene: Enpep  Location: Chr3:129269175-129332720 bp, - strand  Genetic Position: Chr3, 57.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:47424
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exon 1 and intron 1 were replaced by a neomycin selection cassette. Normal protein was undetected in homozygous mutant mice via flow cytometric analysis of bone marrow cells and staining of kidney sections. An assay of bone marrow cell culture supernatents showed no aberrant secretion of any protein product that could have been produced by targeted allele. Assays of renal cells, intestinal enterocytes, and stimulated bone marrow cells confirmed the ablation of aminopeptidase activity. (J:47424)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Enpep Mutation:  38 strains or lines available
Original:  J:47424 Lin Q, et al., T and B cell development in BP-1/6C3/aminopeptidase A-deficient mice. J Immunol. 1998 May 15;160(10):4681-7
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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