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Gadd45gtm1Flv
Targeted Allele Detail
Nomenclature
Symbol: Gadd45gtm1Flv
Name: growth arrest and DNA-damage-inducible 45 gamma; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2182738
Synonyms: GADD45gamma-
Gene: Gadd45g  Location: Chr13:52000714-52002504 bp, + strand  Genetic Position: Chr13, 26.36 cM, cytoband A5-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69475
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 4 and part of exon 3, which encode amino acids 92-159 that are involved in interaction with Map3k4, were replaced with a neomycin resistance gene via homologous recombination. Northern blot analysis of IL-2 activated T cells from homozygous mutant animals showed no detectable gene expression. (J:69475)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gadd45g Mutation:  7 strains or lines available
References
Original:  J:69475 Lu B, et al., GADD45gamma mediates the activation of the p38 and JNK MAP kinase pathways and cytokine production in effector TH1 cells. Immunity. 2001 May;14(5):583-90
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory