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Targeted Allele Detail
Symbol: Ets1tm1Fwa
Name: E26 avian leukemia oncogene 1, 5' domain; targeted mutation 1, Frederick W Alt
MGI ID: MGI:2182735
Synonyms: Ets-1-, Ets-1d
Gene: Ets1  Location: Chr9:32547517-32669116 bp, + strand  Genetic Position: Chr9, 17.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:29736
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 8 and 9, encoding the DNA-binding domain comprised of 110 carboxy terminal amino acids, were deleted by the insertion of a PGK-neo cassette. An absence of transcript was determined in homozygous mutant mice via Northern blot analysis. (J:29736)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ets1 Mutation:  15 strains or lines available
Original:  J:29736 Bories JC, et al., Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature. 1995 Oct 19;377(6550):635-8
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory