Gadd45g^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Gadd45g^tm1Jni
• Name: growth arrest and DNA-damage-inducible 45 gamma; targeted mutation 1, James N Ihle
• MGI ID: MGI:2182734
• Synonyms: Gadd45gamma-deficient
• Gene: Gadd45g Location: Chr13:52000714-52002504 bp, + strand Genetic Position: Chr13, 26.36 cM, cytoband A5-B
• Alliance: Gadd45g^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:68832
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the coding sequence of the gene (from part of exon 1 through part of exon 4) was replaced with a neomycin resistance cassette. Absence of gene expression in Il2-activated T cells from homozygous mutant animals was confirmed by Northern blot analysis using a probe to the coding region of the gene. (J:68832)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gadd45g Mutation: 8 strains or lines available

References

• Original: J:68832 Hoffmeyer A, et al., Gadd45gamma is dispensable for normal mouse development and T-cell proliferation. Mol Cell Biol. 2001 May;21(9):3137-43
• All: 4 reference(s)