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Targeted Allele Detail
Symbol: Cd40lgtm1Flv
Name: CD40 ligand; targeted mutation 1, Richard A Flavell
MGI ID: MGI:2182733
Synonyms: CD154-, CD154KO, CD40L-, CD40L def., Cd40lg-
Gene: Cd40lg  Location: ChrX:57212143-57224042 bp, + strand  Genetic Position: ChrX, 31.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:25010
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 500 base pair BamHI-XbaI fragment, corresponding to bases 368 through 417 of the cDNA, was replaced with a neomycin selection cassette. The encoded protein was undetected via flow cytometry on the surface of activated T cells derived from homozygous mutant mice. (J:25010)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd40lg Mutation:  11 strains or lines available
Original:  J:25010 Xu J, et al., Mice deficient for the CD40 ligand [published erratum appears in Immunity 1994 Oct;1(7):following 613]. Immunity. 1994 Aug;1(5):423-31
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory