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Targeted Allele Detail
Symbol: S1pr3tm1Jch
Name: sphingosine-1-phosphate receptor 3; targeted mutation 1, Jerold Chun
MGI ID: MGI:2182637
Synonyms: lpB3-, s1p3-
Gene: S1pr3  Location: Chr13:51408639-51422797 bp, + strand  Genetic Position: Chr13, 26.12 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:71372
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsSequence encompassing the entire open reading frame, which is contained in the 5' region of exon 2, was flanked by an upstream loxP site in intron 1 and a downstream floxed neo cassette. The entire open reading frame and the neo transgene were excised via cre recombinase mediated deletion. Northern blot analysis and in situ hybridization showed an absence of transcript in homozygous mutant mice. A complete absence of encoded protein was determined via Western blot analysis using antibodies for the amino and carboxy termini. (J:71372)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any S1pr3 Mutation:  4 strains or lines available
Original:  J:71372 Ishii I, et al., Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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