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Hsf2tm1Mmr
Targeted Allele Detail
Nomenclature
Symbol: Hsf2tm1Mmr
Name: heat shock factor 2; targeted mutation 1, Michel Morange
MGI ID: MGI:2182620
Synonyms: Hsf2-
Gene: Hsf2  Location: Chr10:57486385-57513135 bp, + strand  Genetic Position: Chr10, 29.19 cM, cytoband B3-B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76942
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsThe gene is disrupted by insertion of a lacZ-neo cassette into exon 5 via homologous recombination. The gene targeting event results in the disruption of the oligomerization domain at lysine 167 and disruption of one of two nuclear localization signals while HSE-binding activity is retained. The mutant protein is expected to be cytoplasmic and lack trimerization abilities. RT-PCR and Western blot analyses confirmed the absence of gene expression in testes of homozygous mutant animals and homozygous mutant embryos. (J:76942)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hsf2 Mutation:  22 strains or lines available
References
Original:  J:76942 Kallio M, et al., Brain abnormalities, defective meiotic chromosome synapsis and female subfertility in HSF2 null mice. EMBO J. 2002 Jun 3;21(11):2591-601
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory