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Targeted Allele Detail
Symbol: Lhx8tm1Lmgd
Name: LIM homeobox protein 8; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI ID: MGI:2182594
Gene: Lhx8  Location: Chr3:154306294-154330659 bp, - strand  Genetic Position: Chr3, 79.12 cM, cytoband H3-H4
H&E staining of coronal palatal region sections of Lhx8tm1Lmgd/Lhx8tm1Lmgd and wild-type embryos

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:59082
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exons 4 through 6 were replaced with a neomycin selection cassette. (J:59082)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx8 Mutation:  13 strains or lines available
Original:  J:59082 Zhao Y, et al., Isolated cleft palate in mice with a targeted mutation of the LIM homeobox gene lhx8. Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15002-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory