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Targeted Allele Detail
Symbol: Ppp1cctm1Var
Name: protein phosphatase 1, catalytic subunit, gamma isoform; targeted mutation 1, Susannah Varmuza
MGI ID: MGI:2182577
Synonyms: PP1cgamma-
Gene: Ppp1cc  Location: Chr5:122158278-122175273 bp, + strand  Genetic Position: Chr5, 62.2 cM, cytoband F-G1
Germline Transmission:  Earliest citation of germline transmission: J:52211
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence common to both known splice variants was replaced with a neo cassette. The absence of normal transcript in homozygous mice was determined by Northern blot analysis, which showed the presence of a truncated transcript resulting from the aberrant splicing of exons 4 and 7. The splice event was confirmed by RT-PCR and sequence analysis. The truncated transcript encoded 116 fewer amino acids than the normal transcript and had 33 missense mutations. No protein was detected in homozygous mutant mice by Western blot analysis using an antibody directed against the amino terminal region. (J:52211)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp1cc Mutation:  31 strains or lines available
Original:  J:52211 Varmuza S, et al., Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1c gamma gene. Dev Biol. 1999 Jan 1;205(1):98-110
All:  15 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory