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Tbpl1tm1Saco
Targeted Allele Detail
Nomenclature
Symbol: Tbpl1tm1Saco
Name: TATA box binding protein-like 1; targeted mutation 1, Paolo Sassone-Corsi
MGI ID: MGI:2182539
Synonyms: TLF-
Gene: Tbpl1  Location: Chr10:22703879-22731938 bp, - strand  Genetic Position: Chr10, 10.25 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68789
Parent Cell Line:  H1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by insertion of a loxP-flanked PGK-hygro cassette into exon 4 via homologous recombination. The gene targeting event results in truncation of the protein at amino acid 88 and elimination of the DNA binding surface. Gene expression is strongly decreased in brain and testes of homozygous mutant animals as determined by Northern blot. Protein product was not detected in testes of homozygous mutants as determined by Western blot. (J:68789)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbpl1 Mutation:  7 strains or lines available
References
Original:  J:68789 Martianov I, et al., Late arrest of spermiogenesis and germ cell apoptosis in mice lacking the TBP-like TLF/TRF2 gene. Mol Cell. 2001 Mar;7(3):509-15
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory