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Targeted Allele Detail
Symbol: Dnmt3atm2Enl
Name: DNA methyltransferase 3A; targeted mutation 2, En Li
MGI ID: MGI:2182412
Gene: Dnmt3a  Location: Chr12:3806007-3914443 bp, + strand  Genetic Position: Chr12, 1.99 cM, cytoband A2-A3
Germline Transmission:  Earliest citation of germline transmission: J:58298
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTargeting took place in ES cells heterozygous for Dnmt3atm1Enl, originally for the purpose of generating ES cells with both copies of the gene inactivated. A 0.3kb region of the wild-type allele encoding the PC and ENV motifs was replaced with a hygromycin selection cassette via homologous recombination. (J:58298)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dnmt3a Mutation:  112 strains or lines available
Original:  J:58298 Okano M, et al., DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999 Oct 29;99(3):247-57
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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