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Targeted Allele Detail
Symbol: Ncam1tm1Mag
Name: neural cell adhesion molecule 1; targeted mutation 1, Terry Magnuson
MGI ID: MGI:2182406
Synonyms: Ncam-180-, Ncamtm1Cwr
Gene: Ncam1  Location: Chr9:49502136-49798925 bp, - strand  Genetic Position: Chr9, 26.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:37891
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA FRT-flanked neomycin resistance cassette driven by beta-actin replaced exon 18, which is specific to the 180 kDa isoform of the protein. Immunoblot analysis of brain tissues from homozygous mutant mice did not detect the 180 kDa isoform in neonatal and adult tissues, and detected the 140kDa isoform in neonatal tissues, but not in adult tissues. (J:37891)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ncam1 Mutation:  24 strains or lines available
Original:  J:37891 Tomasiewicz H, et al., Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system. Neuron. 1993 Dec;11(6):1163-74
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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