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Targeted Allele Detail
Symbol: Tacr1tm1Sph
Name: tachykinin receptor 1; targeted mutation 1, Stephen P Hunt
MGI ID: MGI:2182395
Synonyms: NK-1-, NK1-
Gene: Tacr1  Location: Chr6:82402334-82560104 bp, + strand  Genetic Position: Chr6, 35.94 cM, cytoband D1
Germline Transmission:  Earliest citation of germline transmission: J:46629
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsExon 1 was disrupted by the insertion of a cassette containing an IRES-lacZ gene and MC1-neo gene. A lack of ligand binding, determined by receptor autoradiography, indicated an absence of encoded protein in the brain and spinal cords of homozygous mutant mice. Immunohistochemical analysis, using an antibody raised against the carboxy terminus confirmed the lack of encoded protein. (J:46629)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tacr1 Mutation:  22 strains or lines available
Original:  J:46629 De Felipe C, et al., Altered nociception, analgesia and aggression in mice lacking the receptor for substance P [see comments]. Nature. 1998 Mar 26;392(6674):394-7
All:  40 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory