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Cyp27b1tm1Dgo
Targeted Allele Detail
Nomenclature
Symbol: Cyp27b1tm1Dgo
Name: cytochrome P450, family 27, subfamily b, polypeptide 1; targeted mutation 1, David Goltzman
MGI ID: MGI:2182323
Synonyms: 1alpha(OH)ase-
Gene: Cyp27b1  Location: Chr10:127048250-127053006 bp, + strand  Genetic Position: Chr10, 74.5 cM
Bone histology of Cyp27b1tm1Dgo/Cyp27b1tm1Dgo mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70030
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 6 through 8, encoding the hormone and heme binding domains, were replaced with a neomycin selection cassette. RT-PCR analysis of total renal RNA showed an absence of transcript in homozygous mutant mice. (J:70030)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyp27b1 Mutation:  21 strains or lines available
References
Original:  J:70030 Panda DK, et al., Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7498-503
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory