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Targeted Allele Detail
Symbol: Nkx6-2tm1Qiu
Name: NK6 homeobox 2; targeted mutation 1, Mengsheng Qiu
MGI ID: MGI:2182286
Synonyms: Nkx6.2-
Gene: Nkx6-2  Location: Chr7:139159292-139162713 bp, - strand  Genetic Position: Chr7, 84.57 cM
Germline Transmission:  Earliest citation of germline transmission: J:69975
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 through 3 were deleted by the insertion of a neomycin selection cassette. RT-PCR analysis and in situ hybridization of embryonic midbrain showed an absence of transcript in homozygous mutant mice. The expression of Nkx6-1 was shown to be unaffected by the targeting event via in situ hybridization. (J:69975)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nkx6-2 Mutation:  11 strains or lines available
Original:  J:69975 Cai J, et al., Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally. Mol Cell Biol. 2001 Jul;21(13):4399-403
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory