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Transgene Detail
Symbol: Tg(SOD1*G85R)74Dwc
Name: transgene insertion 74, Don W Cleveland
MGI ID: MGI:2182172
Synonyms: 74-G85R, Tg(SOD1-G85R)74Dwc
Transgene: Tg(SOD1*G85R)74Dwc  Location: unknown  
Strain of Origin:  Not Applicable
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SOD1*G85R)74Dwc expresses 1 gene
Mutation detailsA 12 kb genomic fragment of human SOD1 carrying the glycine to arginine substitution at amino acid 85 (G85R) associated with familial amyotrophic lateral sclerosis (ALS) was used as the transgene. (J:77600)
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Transgenic animals initially exhibit hindlimb weakness that spreads with rapid progression to forelimbs and results in muscle atrophy and complete paralysis within 2 weeks. Founders 148-G85R and 74-G85R are the highest and lowest expressing transgenic lines, respectively, and differ in onset of clinical symptoms, presumably due to gene dosage. Founder 148-G85R exhibits muscle weakness at 8-10 months of age whereas founder 74-G85R exhibits the phenotype 12-14 months of age. Despite the difference in disease onset both founders show the same rate of disease progression after appearance of initial symptoms.

Original:  J:77600 Bruijn LI, et al., ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 1997 Feb;18(2):327-38
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
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