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Targeted Allele Detail
Symbol: Vdac1tm1Wjc
Name: voltage-dependent anion channel 1; targeted mutation 1, William J Craigen
MGI ID: MGI:2182154
Synonyms: VDAC1-
Gene: Vdac1  Location: Chr11:52360860-52389397 bp, + strand  Genetic Position: Chr11, 31.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:76838
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3.7kb fragment, containing exons 2 through 5, was replaced with a neomycin selection cassette. Northern blot analysis showed the absence of transcript in homozygous mutant mice. (J:76838, J:78058)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vdac1 Mutation:  56 strains or lines available
Original:  J:76838 Weeber EJ, et al., The role of mitochondrial porins and the permeability transition pore in learning and synaptic plasticity. J Biol Chem. 2002 May 24;277(21):18891-7
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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