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Targeted Allele Detail
Symbol: Csnk2a2tm1Dcs
Name: casein kinase 2, alpha prime polypeptide; targeted mutation 1, David C Seldin
MGI ID: MGI:2182135
Synonyms: Csnk2a2-
Gene: Csnk2a2  Location: Chr8:95446096-95490039 bp, - strand  Genetic Position: Chr8, 47.12 cM
Germline Transmission:  Earliest citation of germline transmission: J:57312
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 2.5kb region, containing the promoter region and exons 1 and 2, was replaced by a neomycin selection cassette. The deleted region encoded the start codon and the ATP-binding domain. Northern and Western blot analyses of testicular tissue showed a lack of transcript and protein in homozygous mutant mice. (J:57312)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csnk2a2 Mutation:  15 strains or lines available
Original:  J:57312 Xu X, et al., Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Nat Genet. 1999 Sep;23(1):118-21
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory