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Targeted Allele Detail
Symbol: Ctsktm1Psa
Name: cathepsin K; targeted mutation 1, Paul Saftig
MGI ID: MGI:2182131
Synonyms: Cathk-, CatK-, K-
Gene: Ctsk  Location: Chr3:95499256-95509362 bp, + strand  Genetic Position: Chr3, 40.74 cM
Radiographs and histological analysis of Ctsktm1Psa/Ctsktm1Psa mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:50934
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 7. An absence of transcript generated from this allele was determined by Northern blot and RT-PCR analyses of total bone RNA. Western blot analysis of protein extracts from homozygous mutant bone showed a lack or encoded protein. (J:50934)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctsk Mutation:  7 strains or lines available
Original:  J:50934 Saftig P, et al., Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13453-8
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory