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Transgene Detail
Symbol: Tg(CMV-Scnn1a)1352Rss
Name: transgene insertion 1352, Bernard C Rossier
MGI ID: MGI:2182126
Transgene: Tg(CMV-Scnn1a)1352Rss  Location: unknown  
Strain of Origin:  NMRI
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(CMV-Scnn1a)1352Rss expresses 1 gene
Mutation detailsThe transgene consists of a constituitive and ubiquitous cytomegalovirus promoter, an IgE intron, the rat Scnn1a (alpha ENaC; position -78 to +2149), and simian virus 40 large T antigen polyadenylation sequences. RT-PCR showed reconstitution of expression of the transgene in lung, kidney, skin, and colon tissue. Expression analysis of cardiac tissue showed that Scnn1a transcript is absent in wild-type mice and present in the transgenic mice. Transcript was undetected in liver tissue isolated from wild-type and transgenic mice. Reconstitution was additionally confirmed in lung tissue via in situ hybridization. (J:43583)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:43583 Hummler E, et al., A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11710-5
All:  5 reference(s)

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MGI 6.13
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