Tg(THY1-Prph1)1Jpj
Transgene Detail

Summary

• Symbol: Tg(THY1-Prph1)1Jpj
• Name: transgene insertion 1, Jean-Pierre Julien
• MGI ID: MGI:2182109
• Synonyms: TPer
• Transgene: Tg(THY1-Prph1)1Jpj Location: unknown
• Alliance: Tg(THY1-Prph1)1Jpj page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(THY1-Prph1)1Jpj expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prph (MGI:97774)

• Mutation details: The full mouse Prph1 sequence starting 23 nucleotides upstream from the translation initiation site and ending 2.5 kb downstream of the polyadenylation signal was used for the transgene. Regulatory sequences from human THY1, which include the THY1 promoter and noncoding exons 1 and 2, were used to drive expression of the transgene. (J:58388)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Transgenic animals carry 4 copies of the transgene and begin to develop motor dysfunctions after 2 years of age. Protein expression is increased 4-fold in the ventral roots and 2-fold in the dorsal roots of transgenic animals as determined by Western blot analysis.

References

• Original: J:58388 Beaulieu JM, et al., Late onset death of motor neurons in mice overexpressing wild-type peripherin. J Cell Biol. 1999 Nov 1;147(3):531-44
• All: 2 reference(s)