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Targeted Allele Detail
Symbol: Sox4tm2Cle
Name: SRY (sex determining region Y)-box 4; targeted mutation 2, Hans Clevers
MGI ID: MGI:2182108
Synonyms: Tg2001
Gene: Sox4  Location: Chr13:28948919-28953699 bp, - strand  Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
Germline Transmission:  Earliest citation of germline transmission: J:32741
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct containing a neomycin selection cassette in the opposite orientation and lacking a start codon replaced the 5' region of the gene. Northern blot analysis showed an absence of transcript in the heads of homozygous mutant embryos. (J:32741)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox4 Mutation:  3 strains or lines available
Original:  J:32741 Schilham MW, et al., Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4. Nature. 1996 Apr 25;380(6576):711-4
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory