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Tg(Ckmm-cre)5Khn
Transgene Detail
Nomenclature
Symbol: Tg(Ckmm-cre)5Khn
Name: transgene insertion 5, C Ronald Kahn
MGI ID: MGI:2182095
Synonyms: Ckm-cre, Ckmm-cre, Ckmm-NLS-cre, CreMck, mckCRE, MCK-cre, MCKCre+, MCK-cre5, Tg(Ckm-cre)5Khn, Tg(Ckmm-cre)1Khn
Transgene: Tg(Ckmm-cre)5Khn  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsA 6.5 kb genomic DNA fragment of the Ckmm gene containing the promoter and enhancer 1, untranslated exon 1, 3kb of intron 1 including the enhancer 2 region, and the first 16 bp of exon 2 drives expression of a modified cre with an SV40 large T antigen nuclear localization signal. Expression is directed to the heart and skeletal muscle. (J:51266)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ckm     Summary of all recombinase alleles driven by Ckm.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 321 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
References
Original:  J:51266 Bruning JC, et al., A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell. 1998 Nov;2(5):559-69
All:  335 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory