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Tg(NFH)120Jpj
Transgene Detail
Nomenclature
Symbol: Tg(NFH)120Jpj
Name: transgene insertion 120, Jean-Pierre Julien
MGI ID: MGI:2182067
Transgene: Tg(NFH)120Jpj  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Founder 120 is representative of 2 founders carrying 2 and 3 copies of the transgene. These animals express approximately 50% the amount of endogenous mRNA and exhibit neurological anomalies at 6 months of age.

The phenotype is more severe in homozygous mice verses hemizygous mice, implying a correlation between phenotype and expression levels of NEFH.

References
Original:  J:69180 Cote F, et al., Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis. Cell. 1993 Apr 9;73(1):35-46
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory