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Targeted Allele Detail
Symbol: Ptentm2Mak
Name: phosphatase and tensin homolog; targeted mutation 2, Tak W Mak
MGI ID: MGI:2182005
Synonyms: PTENCo, Ptenf, Ptenfl, Ptenflox, PtenL, PtenloxP
Gene: Pten  Location: Chr19:32757497-32826160 bp, + strand  Genetic Position: Chr19, 28.14 cM
Urothelial hyperplasia and increased apoptosis in bladder epithelium of Ptentm2Mak/Ptentm2Mak Stk11tm1Keis/Stk11tm1Keis Tg(Cyp1a1-cre/ERT)1Dwi/0 mice

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:69471
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsOne loxP site was inserted in intron 3 and a floxed hygromycin selection cassette was inserted in intron 5. The hygromycin selection cassette was removed in ES cells by transient Cre expression, leaving exons 4 and 5 flanked by loxP sites in the final allele. (J:69471)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:  41 strains or lines available
Phenotypic Similarity to Human Syndrome: Cortical Dysplasia (Ptentm2Mak/Ptentm2Mak Tg(Gfap-cre)1Sbk mice, J:149829)
Original:  J:69471 Suzuki A, et al., T cell-specific loss of pten leads to defects in central and peripheral tolerance. Immunity. 2001 May;14(5):523-34
All:  148 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory