Tg(Ttr-Hamp)THnb10Svl
Transgene Detail

Summary

• Symbol: Tg(Ttr-Hamp)THnb10Svl
• Name: transgene insertion THnb10, Sophie Vaulont
• MGI ID: MGI:2181880
• Synonyms: THnb10
• Transgene: Tg(Ttr-Hamp)THnb10Svl Location: unknown
• Alliance: Tg(Ttr-Hamp)THnb10Svl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-Hamp)THnb10Svl expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Hamp (MGI:1933533)

• Mutation details: The full-length mouse cDNA was used as a transgene. The transgene was fused to mouse transthyretin regulatory sequences to drive liver-specific expression. (J:75776)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Founder THnb10 is representative of a group of transgenic lines (Thnb2, 3, 4, 10, 25, and 29) that exhibit pale skin and die a few hours after birth. All trangenic lines contain at least 2 copies of the transgene.

References

• Original: J:75776 Nicolas G, et al., Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4596-601
• All: 1 reference(s)