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Targeted Allele Detail
Symbol: Sp1tm1Phi
Name: trans-acting transcription factor 1; targeted mutation 1, Sjaak Philipsen
MGI ID: MGI:2181866
Synonyms: Sp1-
Gene: Sp1  Location: Chr15:102314751-102344839 bp, + strand  Genetic Position: Chr15, 57.55 cM
Germline Transmission:  Earliest citation of germline transmission: J:40354
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exons encoding the zinc-finger domains and an essential carboxy terminal region were replaced with a lacZ-neo fusion gene. The lacZ gene was adjoined to a splice acceptor site and IRES, allowing expression and translation of lacZ. (J:40354)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sp1 Mutation:  252 strains or lines available
Original:  J:40354 Marin M, et al., Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell. 1997 May 16;89(4):619-28
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory