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Rhotm1Phm
Targeted Allele Detail
Nomenclature
Symbol: Rhotm1Phm
Name: rhodopsin; targeted mutation 1, Peter Humphries
MGI ID: MGI:2181812
Synonyms: R-, Rho-
Gene: Rho  Location: Chr6:115931748-115940036 bp, + strand  Genetic Position: Chr6, 53.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38098
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette under the control of a polymerase II promoter was inserted at codon 135 in exon 2. RT-PCR analysis of total RNA derived from ocular tissue showed an absence of transcript in homozygous mutant mice. A lack of encoded protein was determined in homozygous mutant mice via immunocytochemical staining of retinal sections. (J:38098)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rho Mutation:  13 strains or lines available
References
Original:  J:38098 Humphries MM, et al., Retinopathy induced in mice by targeted disruption of the rhodopsin gene [see comments]. Nat Genet. 1997 Feb;15(2):216-9
All:  67 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory