Gp1ba^tm1Ware
Targeted Allele Detail

Summary

• Symbol: Gp1ba^tm1Ware
• Name: glycoprotein 1b, alpha polypeptide; targeted mutation 1, Jerry Ware
• MGI ID: MGI:2181691
• Synonyms: GP1b^tm1, GP Ibalpha^-, GPIbalpha^-, mGP Ibalpha^-, mGPIb-alpha^null
• Gene: Gp1ba Location: Chr11:70529948-70532862 bp, + strand Genetic Position: Chr11, 43.2 cM
• Alliance: Gp1ba^tm1Ware page

Transmission electron microscopy of mature megakaryocytes from Gp1ba^tm1Ware/Gp1ba^tm1Ware mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63389
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced the entire open reading frame of the endogenous locus. Northern blot analysis of bone marrow cells obtained from homozygous mutant mice showed an absence of transcript. (J:63389)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gp1ba Mutation: 27 strains or lines available

References

• Original: J:63389 Ware J, et al., Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2803-8
• All: 41 reference(s)