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Targeted Allele Detail
Symbol: Gp1batm1Ware
Name: glycoprotein 1b, alpha polypeptide; targeted mutation 1, Jerry Ware
MGI ID: MGI:2181691
Synonyms: GP1btm1, GP Ibalpha-, GPIbalpha-, mGP Ibalpha-, mGPIb-alphanull
Gene: Gp1ba  Location: Chr11:70639122-70642036 bp, + strand  Genetic Position: Chr11, 43.2 cM
Transmission electron microscopy of mature megakaryocytes from Gp1batm1Ware/Gp1batm1Ware mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:63389
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced the entire open reading frame of the endogenous locus. Northern blot analysis of bone marrow cells obtained from homozygous mutant mice showed an absence of transcript. (J:63389)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gp1ba Mutation:  17 strains or lines available
Original:  J:63389 Ware J, et al., Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome. Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2803-8
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory