Tg(RHO)ATpd
Transgene Detail

Summary

• Symbol: Tg(RHO)ATpd
• Name: transgene insertion A, Thaddeus P Dryja
• MGI ID: MGI:2181677
• Synonyms: NHR-A, Tg(RHO-NHR)ATpd
• Transgene: Tg(RHO)ATpd Location: unknown
• Alliance: Tg(RHO)ATpd page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(RHO)ATpd expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RHO (6010)

  Rho	(MGI:97914)

• Mutation details: The entire coding region of normal human rhodopsin (NHR) was used for the transgene. The transgene includes 4.8 kb of upstream sequence and 6.2 kb of downstream sequence. Two lines, A and H, were established. (J:76722)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The mutant line A expresses 5x the amount of endogenous rhodopsin. Mutant animals exhibit severe retinitis pigmentosa.

References

• Original: J:76722 Olsson JE, et al., Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov;9(5):815-30
• All: 4 reference(s)