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Tg(RHO-P23H)DTpd
Transgene Detail
Nomenclature
Symbol: Tg(RHO-P23H)DTpd
Name: transgene insertion D, Thaddeus P Dryja
MGI ID: MGI:2181671
Synonyms: P23H-D
Transgene: Tg(RHO-P23H)DTpd  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Mutant lines D, E, and L harboring the mutant human rhodopsin gene were constructed. Lines D and E express 3x and 1x the amount of endogenous rhodopsin, respectively, resulting in severe retinitis pigmentosa. Line L expresses 1/6x the amount of endogenous rhodopsin and exhibits a mild disease phenotype.

References
Original:  J:76722 Olsson JE, et al., Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov;9(5):815-30
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory