About   Help   FAQ
Ireb2tm1Roua
Targeted Allele Detail
Nomenclature
Symbol: Ireb2tm1Roua
Name: iron responsive element binding protein 2; targeted mutation 1, Tracey Rouault
MGI ID: MGI:2181660
Synonyms: Ireb2-, IRP-2-, IRP2-
Gene: Ireb2  Location: Chr9:54863755-54912534 bp, + strand  Genetic Position: Chr9, 29.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67313
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin cassette deleted portions of exon 3 and 4. Northern blot analysis showed the presence of a larger transcript, containing the neomycin gene, in homozygous mutant mice. A lack of Ireb2 protein and normal levels of Ireb1 was determined by Western blot analysis of fibroblast lysates derived from homozygous mutant mice. (J:67313)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ireb2 Mutation:  33 strains or lines available
References
Original:  J:67313 LaVaute T, et al., Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001 Feb;27(2):209-14
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory