Bace1^tm1Slr
Targeted Allele Detail

Summary

• Symbol: Bace1^tm1Slr
• Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Steven L Roberds
• MGI ID: MGI:2181643
• Gene: Bace1 Location: Chr9:45749878-45775694 bp, + strand Genetic Position: Chr9, 25.22 cM
• Alliance: Bace1^tm1Slr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77414
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette, flanked by FLP recombinase target (FRT) sites was inserted into intron 3. An additional FRT site was inserted into intron 8, situating exons 4 through 8 in between FRT sites. Heterozygous mice were utilized to generate mice possessing Bace^tm1.1Slr. (J:77414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bace1 Mutation: 30 strains or lines available

References

• Original: J:77414 Roberds SL, et al., BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 1;10(12):1317-24
• All: 2 reference(s)