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Dhcr7tm1Fdp
Targeted Allele Detail
Nomenclature
Symbol: Dhcr7tm1Fdp
Name: 7-dehydrocholesterol reductase; targeted mutation 1, Forbes D Porter
MGI ID: MGI:2181641
Synonyms: Dhcr7-
Gene: Dhcr7  Location: Chr7:143823145-143848410 bp, + strand  Genetic Position: Chr7, 88.33 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68084
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
    A PGK-neo cassette replaced all of exons 3 and 4 as well as a portion of exon 5. (J:68084)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 29 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dhcr7 Mutation:  6 strains or lines available
References
Original:  J:68084 Wassif CA, et al., Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Hum Mol Genet. 2001 Mar 15;10(6):555-64
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory