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Slc12a2tm1Bhk
Targeted Allele Detail
Nomenclature
Symbol: Slc12a2tm1Bhk
Name: solute carrier family 12, member 2; targeted mutation 1, Beverly H Koller
MGI ID: MGI:2181636
Synonyms: Slc12a2delta1065-1137
Gene: Slc12a2  Location: Chr18:57878678-57946821 bp, + strand  Genetic Position: Chr18, 32.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60671
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 24 and 25, encoding amino acids in the carboxyl-terminal cytoplasmic domain (residues 1065 through 1137), were replaced with a neomycin selection cassette. Northern blot analysis of salivary gland total RNA showed normal levels of a truncated transcript. RT-PCR analysis, using probes flanking the targeted region indicated a deletion of 195 coding-nucleotides in mutant mice. (J:60671)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc12a2 Mutation:  23 strains or lines available
References
Original:  J:60671 Pace AJ, et al., Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. J Clin Invest. 2000 Feb;105(4):441-50
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory