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Targeted Allele Detail
Symbol: Akt1tm1Nhy
Name: thymoma viral proto-oncogene 1; targeted mutation 1, Nissim Hay
MGI ID: MGI:2181580
Synonyms: Akt1-, Akt1 KO
Gene: Akt1  Location: Chr12:112653821-112674884 bp, - strand  Genetic Position: Chr12, 61.2 cM, cytoband F1-F2
Germline Transmission:  Earliest citation of germline transmission: J:71404
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 8 through 13 were replaced with a neomycin selection cassette. Encoded protein was not detected by Western blot analysis of fibroblasts isolated from homozygous mutant embryos. (J:71404)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Akt1 Mutation:  24 strains or lines available
Original:  J:71404 Chen WS, et al., Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev. 2001 Sep 1;15(17):2203-8
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory