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Sox2tm2Skn
Targeted Allele Detail
Nomenclature
Symbol: Sox2tm2Skn
Name: SRY (sex determining region Y)-box 2; targeted mutation 2, Silvia K Nicolis
MGI ID: MGI:2181440
Synonyms: allele 2, Sox2Beta-geo
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:62026
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region was replaced by a construct containing a beta-geo fusion gene, lacking a promoter. Recombination of the construct left the 5' flanking region intact, enabling the expression of the beta-geo transgene to be under the control of the endogenous promoter and regulatory sequences. (J:62026)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  20 strains or lines available
References
Original:  J:62026 Zappone MV, et al., Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells. Development. 2000 Jun;127(11):2367-82
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory