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Rpe65tm1Tmr
Targeted Allele Detail
Nomenclature
Symbol: Rpe65tm1Tmr
Name: retinal pigment epithelium 65; targeted mutation 1, T Michael Redmond
MGI ID: MGI:2181399
Synonyms: Rpe65-
Gene: Rpe65  Location: Chr3:159599175-159625321 bp, + strand  Genetic Position: Chr3, 82.52 cM, cytoband H4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51293
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1-3 of the gene were replaced with a PGK-neo cassette via homologous recombination. RT-PCR analysis of whole mouse eyes confirmed the null allele in homozygous mutant animals. (J:51293)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rpe65 Mutation:  5 strains or lines available
References
Original:  J:51293 Redmond TM, et al., Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle. Nat Genet. 1998 Dec;20(4):344-51
All:  89 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory