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Targeted Allele Detail
Symbol: Hnf1btm2Mya
Name: HNF1 homeobox B; targeted mutation 2, Moshe Yaniv
MGI ID: MGI:2181390
Synonyms: Hnf1betadel, vHNF1/del
Gene: Hnf1b  Location: Chr11:83850209-83905917 bp, + strand  Genetic Position: Chr11, 51.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:58080
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA floxed neomycin selection cassette and an additional loxP site were inserted at the endogenous locus via homologous recombination. Deletion of the promoter region, the transcription initiation site, and exon 1 was achieved by the transient expression of cre recombinase in ES cells. (J:58080)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:  3 strains or lines available
Original:  J:58080 Coffinier C, et al., Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation. Development. 1999 Nov;126(21):4785-94
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory