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Targeted Allele Detail
Symbol: Nr1h3tm1Djm
Name: nuclear receptor subfamily 1, group H, member 3; targeted mutation 1, David J Mangelsdorf
MGI ID: MGI:2181380
Synonyms: LXRalpha (-), Nr1h3-
Gene: Nr1h3  Location: Chr2:91184061-91202834 bp, - strand  Genetic Position: Chr2, 50.52 cM
Germline Transmission:  Earliest citation of germline transmission: J:47971
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3-6 encoding the DNA-binding and ligand-binding domains (amino acids 87-327) were replaced with a neomycin resistance gene via homologous recombination. Northern blot and Western blot analysis of liver from homozygous mutant animals verified the absence of mRNA and protein expression. (J:47971)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Nr1h3 Mutation:  18 strains or lines available
Original:  J:47971 Peet DJ, et al., Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Cell. 1998 May 29;93(5):693-704
All:  76 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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