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Targeted Allele Detail
Symbol: Pdx1tm1Cvw
Name: pancreatic and duodenal homeobox 1; targeted mutation 1, Christopher VE Wright
MGI ID: MGI:2181360
Synonyms: Ipf1-, pdx-1 -, pdxXBko-
Gene: Pdx1  Location: Chr5:147206907-147212658 bp, + strand  Genetic Position: Chr5, 86.84 cM
Pancreatic hypoplasia in Pdx1tm1Cvw/Pdx1tm1.1Stof mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:32017
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 2 with a neomycin resistance cassette resulting in the deletion of the DNA-binding homeodomain. Immunostaining of E9.5 embryos with antibodies directed against the N-terminus of the protein did not detect protein product. (J:32017)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  28 strains or lines available
Original:  J:32017 Offield MF, et al., PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development. 1996 Mar;122(3):983-95
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory