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Bmpr1atm2.2Bhr
Targeted Allele Detail
Nomenclature
Symbol: Bmpr1atm2.2Bhr
Name: bone morphogenetic protein receptor, type 1A; targeted mutation 2.2, Richard R Behringer
MGI ID: MGI:2181295
Synonyms: Bmpr1a-, deltae2, deltaexon2
Gene: Bmpr1a  Location: Chr14:34411061-34503336 bp, - strand  Genetic Position: Chr14, 20.81 cM
Joint defects in Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre-ALPP)1Kng/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75074
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsHomologous recombination introduced a floxed neomycin resistance cassette into intron 2, and a single loxP site into intron 1. Cre-mediated recombination in vivo under the control of a CMV promoter excised the neo cassette and exon 2, which encodes roughly a third of the extracellular domain of the receptor within the ligand-binding domain. (J:75074)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmpr1a Mutation:  59 strains or lines available
References
Original:  J:75074 Mishina Y, et al., Generation of Bmpr/Alk3 conditional knockout mice. Genesis. 2002 Feb;32(2):69-72
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory