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Targeted Allele Detail
Symbol: Hptm1Skl
Name: haptoglobin; targeted mutation 1, Sai-Kiang Lim
MGI ID: MGI:2181293
Synonyms: Hp-, Hp 0
Gene: Hp  Location: Chr8:109575128-109579172 bp, - strand  Genetic Position: Chr8, 57.11 cM
Germline Transmission:  Earliest citation of germline transmission: J:49888
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-4 were replaced with a neomycin resistance gene via homologous recombination. RT-PCR analysis of liver and Western blot analysis of plasma from homozygous mutant animals verified the absence of gene expression from the null allele. (J:49888)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hp Mutation:  8 strains or lines available
Original:  J:49888 Lim SK, et al., Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 1998 Sep 15;92(6):1870-7
All:  18 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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