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Gpd2tm1Tka
Targeted Allele Detail
Nomenclature
Symbol: Gpd2tm1Tka
Name: glycerol phosphate dehydrogenase 2, mitochondrial; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2181289
Synonyms: mGPDH-
Gene: Gpd2  Location: Chr2:57237678-57370719 bp, + strand  Genetic Position: Chr2, 31.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75839
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe gene was disrupted by insertion of a PGK-neo cassette into exon 5 via homologous recombination. The absence of protein expression was verified by Western blot and enzyme assay of islet samples from homozygous mutant animals. (J:75839)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gpd2 Mutation:  49 strains or lines available
References
Original:  J:75839 Eto K, et al., Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science. 1999 Feb 12;283(5404):981-5
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory