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Tnxbtm1Jbrs
Targeted Allele Detail
Summary
Symbol: Tnxbtm1Jbrs
Name: tenascin XB; targeted mutation 1, James Bristow
MGI ID: MGI:2181283
Synonyms: Tnxb-
Gene: Tnxb  Location: Chr17:34879431-34938789 bp, + strand  Genetic Position: Chr17, 18.24 cM
Alliance: Tnxbtm1Jbrs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75812
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-6 were replaced with a PGK-neo-lacZ cassette via homologous recombination. The absence of mRNA and protein from skin of homozygous mutant animals was verified by Northern and Western blot analysis. (J:75812)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnxb Mutation:  183 strains or lines available
References
Original:  J:75812 Mao JR, et al., Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition. Nat Genet. 2002 Apr;30(4):421-5
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory